Lab News

Our theoretical work on rate maximisation in metabolism has been published in Plos Computational Biology. In this work, we took a very general approach to ask a very specific question: we included genome-scale metabolic networks, complicated enzyme kinetics, and arbitrary constraints on enzyme expression, and then asked what metabolism looks like for a microorganism that

Some of us in the COMBINE community did and this paper is the result: Harmonizing semantic annotations for computational models in biology – Briefings in Bioinformatics – 21 November 2018.

7-10-2018 Het NK Duathlon werd vandaag een prooi voor Daan de Groot. De Groot trok tijdens het fietsen de wedstrijd naar zich toe. Bij de mannen ging Wesley Mols na het startschot er direct hard vandoor, om met een ruime marge aan het fietsen te kunnen beginnen. Achter hem maakte De Groot samen met Hellas-ploeggenoot

Two papers about genome-scale reconstruction and analysis were published by Sebastián Mendoza in March 20th and May 23th. These articles are entitled “Mapping the Physiological Response of Oenococcus oeni to Ethanol Stress Using an Extended Genome-Scale Metabolic Model” and “Traceability, reproducibility and wiki-exploration for “à-la-carte” reconstructions of genome-scale metabolic models“, respectively. Both papers were submitted while Sebastián

For those of you who do not know Daan. He is a PhD student in our lab, working on a mathematical theory about optimal metabolism for microbial growth-rate maximisation and its experimental testing. One of the principles underlying his theory is optimal allocation of limited resources for the synthesis of metabolic enzymes. What turns out