Lab News

We recently published an article in which we reviewed the different approaches that describe a puzzling metabolic phenomenon called overflow metabolism: (https://doi.org/10.1007/s00018-019-03380-2). Many different organisms secrete ‘overflow products’ in conditions where they grow and reproduce fast. For example, many yeasts produce ethanol, Escherichia coli produces acetate, and cancer cells produce lactate. This behaviour seems counter-intuitive

The System Bioinformatics section has a new name and from now on will be known as: Systems Biology Lab

Systeembioinformaticus Daan de Groot met Self-organising adaptation: a universal mechanism for microbial protein expression regulation Cellen kunnen zich aanpassen aan, en groeien in, een verbluffende hoeveelheid omgevingen. Dit lijkt, gezien de eenvoud van individuele cellen, een onmogelijke prestatie. Maar hoe zit dit als een populatie cellen gaat samenwerken? De onderzoekers stellen een universeel mechanisme voor

Two papers were recently published by Chrats about microbial communities. In the first paper, the authors show how microbial communities change during wine fermentations, what are the differences in microbial composition between vineyards and which ones are the species that are present during problematic fermentations. In the second paper, which is a first-authorship for Chrats,

JBAH-Vol.9 No.10 2019.pdf Journal of Biology, Agriculture and Healthcare www.iiste.org Vol.9, No.10, 2019 From Functional Potential of Soil Bacterial Communities Towards Petroleum Hydrocarbons Bioremediation Abstract Molecular ecology researches are rapidly advancing the knowledge of microorganisms associated with petroleum hydrocarbon degradation, one of the major large-scale pollutants in terrestrial ecosystems. The design and monitoring of bioremediation

Our theoretical work on rate maximisation in metabolism has been published in Plos Computational Biology. In this work, we took a very general approach to ask a very specific question: we included genome-scale metabolic networks, complicated enzyme kinetics, and arbitrary constraints on enzyme expression, and then asked what metabolism looks like for a microorganism that