Willi, Brett, Frank and Bas have written a review on constraint-based modelling in the Journal of The Royal Society Interface The paper can be found here
Lab News
Bas moved to a new house with a view over the Rhine and gave a housewarming party for the group. “Good food, good wine, good company and a great venue” summarizes the party, according to Brett.
Jurgen is the senior author on a new book chapter that describes how mathematical modelling can help understand metabolism in parasites and guide drug target identification. The chapter focusses on recent advances for Trypanosoma brucei and Plasmodium Falciparum The chapter is part of a book on “Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery: From
In July, Eva Mooij and Mariah Kes joint our lab to do a short research programme for their honours programme. They worked together with Marijke and Jurgen on glycogen, ammonium and urea measurements in liver cancer cell cultures. They did a great job and it was good to have them in our lab (and thanks
Marijke, our senior technician, is never old enough to learn new techniques. Here she proudly presents her first fermentor -still to be tested:-) She will run controlled batch experiments for the EcoYeast project funded by Era-IB (industrial biotechnology).
On Wednesday, June 29, Frank gave his inaugural speech for this University Research Chair in Interdisciplinary Life Sciences. The speech was in Dutch and with it came a written text. The day ended with a party where Frank received two wonderful gifts from the department and other colleagues: a glider (sailplane) flight and a picture of
Theoretical work from two former PhD students in the lab, Meike Wortel and Evert Bosdriesz is now published in Nature Scientific Reports (link to paper). It provides a theory that links molecular networks -using metabolic control analysis- and selection pressure in the chemostat. It is also shown that co-existence of fermenters and respirers can occur in population dynamical
Bas gave a 1 hour tutorial on stoichiometric modelling and flux balance analysis at the Whole Cell Modelling Course in Barcelona. The lecture was taped. It is really basic, but one of the students from the US told Bas that his talk alone was worth the trip over the ocean. Well, that must have been