Niclas Nordholt / PhD student

Niclas Nordholt

Contact details

O2 building, room 01W58
T: +31 20 5988323
F: +31 20 59 87229






Current work

Optimal resource allocation leads to optimal growth
Optimal resource allocation leads to optimal growth

I am investigating the interplay between (heat) stress management and the central carbon metabolism in Bacillus subtilis as part of the AMBER ITN.
When competing for growth rate, microorganisms should maximize their limited amount of resources invested into growth while still maintaining other vital functions in the cell with minimal protein expenditure. This means, a cell that is able to solve the problem of resource allocation optimally will always outgrow its competitors. I want to test whether B. subtilis is able to optimally allocate its resources under stress conditions, specifically heat stress. The experimental results are supplemented with small, tailor made models to understand the underlying mechanisms.


About me

I am a PhD student in Frank Bruggeman’s group as part of the Systems Bioinformatics group of the Teusink lab at the VU University in Amsterdam. Before that, I did a BSc in Bioinformatics and Genome Research in 2011 and a MSc in Genome Based Systems Biology in 2013, both at the Bielefeld University, Germany. During my BSc and MSc theses I have been working on the genetics of flavonoid biosynthesis in Arabidopsis thaliana seeds. In the Teusink lab I am working on Bacillus subtilis.



  1. van Boxtel, C, van Heerden, JH, Nordholt, N, Schmidt, P, Bruggeman, FJ. Taking chances and making mistakes: non-genetic phenotypic heterogeneity and its consequences for surviving in dynamic environments. J R Soc Interface. 2017;14 (132):. doi: 10.1098/rsif.2017.0141. PubMed PMID:28701503 .
  2. Rabbers, I, van Heerden, JH, Nordholt, N, Bachmann, H, Teusink, B, Bruggeman, FJ et al.. Metabolism at evolutionary optimal States. Metabolites. 2015;5 (2):311-43. doi: 10.3390/metabo5020311. PubMed PMID:26042723 PubMed Central PMC4495375.
  3. Appelhagen, I, Nordholt, N, Seidel, T, Spelt, K, Koes, R, Quattrochio, F et al.. TRANSPARENT TESTA 13 is a tonoplast P3A -ATPase required for vacuolar deposition of proanthocyanidins in Arabidopsis thaliana seeds. Plant J. 2015;82 (5):840-9. doi: 10.1111/tpj.12854. PubMed PMID:25891958 .
  4. Appelhagen, I, Thiedig, K, Nordholt, N, Schmidt, N, Huep, G, Sagasser, M et al.. Update on transparent testa mutants from Arabidopsis thaliana: characterisation of new alleles from an isogenic collection. Planta. 2014;240 (5):955-70. doi: 10.1007/s00425-014-2088-0. PubMed PMID:24903359 .
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