Constraint-based modelling is a popular methodology used in systems biology whose stock in trade is the genome-scale model. However an ongoing problem in this field is that no formal standard exists for encoding such models. Brett Olivier together with Frank Bergmann have led the development of an extension to the Systems Biology Markup Language (SBML), a widely used format for encoding and exchanging mathematical models, that for the first time allows these models to be encoded and annotated in a standard way.
Version 1 of this extension, the SBML Level 3 Flux Balance Constraints (FBC) package has now been published.
BG Olivier, FT Bergmann, (2015) The Systems Biology Markup Language (SBML) Level 3 Package: Flux Balance Constraints, Journal of integrative bioinformatics 12 (2), 269
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