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1. Self-organisation of metabolism, via regulation of gene activity and enzyme activity by metabolic intermediates.
2. Maximisation of cellular fitness, by tuning of stress-response, adaptation and cell-growth activities.
3. Adaptive phenotypic diversification of isogenic populations of microorganisms, using single-cell microscopy.
4. Physiology of single cells and its relation to population properties: growth, gene-activity, and cell-to-cell variability.
5. Theory, software, algorithms and mathematical-modelling methods, to support interests 1 to 4: genome-scale modelling, dynamic models of metabolism regulation, statistical biophysics.
6. Experimental methods, bacterial physiology, fluorescence microscopy, single-molecule methods.
My curriculum vitae and contact information can be found here.
Use this link Pubmed search query to find my publication list.
RECENT REVIEW ABOUT OUR MAIN RESEARCH
We recently wrote a perspective, or review, about what the underlying principles of microbial physiology might be. It is the culmination of about a decade of thinking about what makes bacteria tick, so to speak. You can find it here: final version 19022020 FB.
TEACHING AND COURSE INFORMATION
The teaching material for the 3-day From Enzyme Kinetics to Models of Metabolism from June 21-23 in Delft can be found Course information From Enzyme Kinetics to Models of Metabolism.