Lab News

Our lab has been rather successful lately with grants. Frank obtained a new EraSysApp grant for yeast systems biology (PD for 2 years), Bas got a STW proposal funded (1 PhD still open) for developing methods to select for product yield using our water-in-oil emulsion system (see Bachmann PNAS 2013). Bas is still looking for a

Coco van Boxtel wins the NWO-STAR Master student competition (together with three others) for her proposal on scheduling antibiotic drugs to fight microbial infections. STAR is an initiative of NWO, the Dutch funding agency, from which our Institute (AIMMS) obtained a grant to support 4 PhD projects on antimicrobial research.

four of us (Frank, Bas, Johan and Coco) have visited the lab of Eric van Nimwegen in Basel to see the “Mother Machine” in action and to discuss single-cell growth, regulation of gene expression and many more things. Very useful and enjoyable!

In this PLoS Comp Bio paper, we study how metabolic constraints and optimisation objectives influence optimal states of metabolism and how those optimal states can be expressed in terms of metabolic routes. Optimal states are often represented by optimal-solution spaces, which are mathematical objects that cannot be readily interpreted. We express such solution spaces in terms of

Curious which papers the lab produced? Try this pubmed query. You will find our new work on: Integrative Omics analysis of L lactis at different growth rates in the chemostat Microbial community modelling Solution spaces of genome-scale models Optimality principles of nutrient-uptake and growth rate Single-cell measurement of single RNA molecules